Inclusion Criteria:
* Diagnosis of Onchocerca volvulus infection at time of Screening:
* Presence of at least one excisable subcutaneous nodule/ onchocercoma detected on palpation;
* O. volvulus infection diagnosed by skin snip method: documented mfpositivity on skin assessment on at least 2 out of 4 skin snips.
* Body weight \> 40 kg at Screening.
* For women of child-bearing potential, acceptance of the requirement to use a highly effective form of birth control from Day 0 until at least 1 month after the final intake of study drug (Part 1: day 43; Part 2: 1 month after the administration of ivermectin or matching placebo at the Month 6 visit). Choice of birth control method must be clearly documented.
Exclusion Criteria:
* Participation in any studies other than purely observational studies within 3 months prior to Screening, or during the trial, or within 5 times the half-life of the drug tested in the previous clinical trial or is currently in the follow-up period for any clinical trial.
* Any vaccination within 4 weeks prior to investigational medicinal product (IMP) administration.
* Acute infection and/or febrile illness requiring therapy within 14 days prior to IMP administration.
* Administration of medication or herbal preparations as follows:
* Administration of any medication (with the exception of diclofenac, paracetamol, ibuprofen and aspirin) or herbal preparation within 14 days prior to IMP administration;
* Use of strong CYP3A inhibitors or inducers including but not limited to ritonavir, ketoconazole, rifampicin, phenytoin, phenobarbital, carbamazepine, cimetidine within 14 days or 10 half-lives, whichever is longer, prior to IMP administration;
* Use of other drugs known to interact with albendazole i.e. praziquantel, theophylline or dexamethasone, within 14 days or 10 half-lives, whichever is longer, prior to IMP administration;
* Antifilarial therapies, or medication that may have an antifilarial effect.
* Requirement for and inability to avoid ivermectin during the first 6 months after IMP administration. Requirement for albendazole during the first 28 days after IMP administration or more than one dose per year thereafter given in MDA.
* Presence of any of the following at Screening, that could interfere with the objectives of the trial or the safety of the participant, in the opinion of the Investigator:
* Clinically significant abnormal physical and/or neurological examination or laboratory findings;
* Any clinically significant medical condition. Including, but not limited to significant acute or chronic liver or kidney condition or cardiovascular disease, active infection, current or previous epilepsy, known human immunodeficiency virus infection, disclosed by review of medical history or concomitant medication.
* Ophthalmological history or conditions that could interfere with the objectives of the trial or compromise the safety of the subject in the opinion of the Investigator, assessed at Screening.
* History of drug or alcohol abuse within 6 months prior to IMP administration.
* Use of alcohol within 48 hours and/or use of drugs of abuse within 15 days before IMP administration.
* Clinically significant history of cardiac abnormality, and/or relevant pathological abnormalities in the ECG in the screening period.
* Abnormal laboratory test results at Screening.
* History of severe drug allergy, non-allergic drug reactions, severe adverse reaction to any drug, or multiple drug allergies.
* Known hypersensitivity to any ingredient of the IMPs, including the active ingredient of ABBV-4083, macrolides, albendazole or to ivermectin or to any medication used during the study.
* Blood donation within 8 weeks prior to Screening or blood transfusion received within 1 year prior to Screening.
* Coincidental infection with high Loa loa load at Screening.
* Current hyperreactive onchodermatitis or severe manifestation due to onchocerciasis.
* Any other past or current condition that the Investigator feels would exclude the participant from the study or place the subject at undue risk.
* For women of child-bearing potential: pregnant, based on date of last menstrual period, and pregnancy test prior to first intake of IMP, or breastfeeding.
* Unwilling or unable to comply with the requirements of the study protocol for the entire duration of the study, in the opinion of the Investigator.
* Unable to participate in the study as per local law, if applicable.
