A Study to Assess Prevalence of a Specific Protein Overexpression in Adult Participants With Non-Small Cell Lung Cancer

Study Identifier
H24-281
CT.gov Identifier
NCT06068842
EudraCT Identifier
Not available
EUCTIS ID
Not available
For general inquiries, please contact

844-663-3742 or [email protected]

Study Complete

Study Details

Medical Condition
  • Lung Cancer - Non-Small Cell Lung Cancer (NSCLC)
    • Study Drug
    N/A
    Phase
    N/A
    Sex
    Female & Male
    Age
    18+ years
    Inclusion and Exclusion Criteria
    Inclusion Criteria:
    * Previously consented and/or prospective collection of consent for research use of banked biological materials and clinical data. * Confirmed advanced and/or metastatic non-squamous (NSQ) non-small cell lung cancer (NSCLC). * Has formalin-fixed paraffin-embedded (FFPE) tissue collected since 2019.
    Exclusion Criteria:
    * Specimens collected before 2019. * Insufficient specimen tissue for testing. * Insufficient specimen quality (e.g., not 4-5 µm in thickness) which precludes testing. * Adenosquamous and sarcomatous histologies of NSCLC.

    Protocol Summary

    Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80%-85% of lung cancers cases of which 60% are non-squamous (NSQ). This study will evaluate the prevalence of mesenchymal epithelial transition (MET) overexpression (OE) in adult participants with advanced or metastatic NSQ NSCLC.

    Archived tissue biopsies will be tested for MET OE and data from approximately 500 participants will be collected. No participants will be enrolled in this study.

    Participants' charts will be reviewed. No drug will be administered as a part of this study. The duration of the study will be approximately 15 months.

    There is no additional burden for participants in this trial.

    Study Locations

    Location
    Status
    Location
    Hospital Italiano de Buenos Aires /ID# 256999
    Ciudad Autonoma Buenos Aires, Buenos Aires F.D., Argentina, 1199
    Status
    Not applicable
    Location
    Instituto Alexander Fleming /ID# 256295
    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., Argentina, 1426
    Status
    Not applicable
    Location
    Irmandade da Santa Casa de Misericordia de Porto Alegre /ID# 256487
    Porto Alegre, Rio Grande Do Sul, Brazil, 90020-090
    Status
    Not applicable
    Location
    Hospital Alemao Oswaldo Cruz /ID# 256486
    São Paulo, Brazil, 01323-020
    Status
    Not applicable
    Location
    Nova Scotia Health Authority /ID# 256950
    Halifax, Nova Scotia, Canada, B3H 1V8
    Status
    Not applicable
    Location
    Institut universitaire de cardiologie et de pneumologie de Québec - Université L /ID# 257872
    Québec, Quebec, Canada, G1V 4G5
    Status
    Not applicable
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