Study of Veliparib in Combination With Nivolumab and Platinum Doublet Chemotherapy in Participants With Metastatic or Advanced Non-Small Cell Lung Cancer (NSCLC)
Study Identifier
M15-534
CT.gov Identifier
EudraCT Identifier
EUCTIS ID
Not available
For general inquiries, please contact
Study Complete
Study Details
Medical Condition
Study Drug
Phase
Phase 1
Sex
Female & Male
Age
18+ years
Protocol Summary
This study seeks to establish the recommended Phase 2 dose (RPTD) of veliparib in combination with nivolumab and platinum doublet chemotherapy (carboplatin/paclitaxel or carboplatin/pemetrexed) (Phase 1 portion) and to assess whether the addition of nivolumab to veliparib in combination with platinum doublet chemotherapy results will improve progression free survival (PFS) compared to veliparib with platinum doublet chemotherapy alone in participants with metastatic or advanced Non-small Cell Lung Cancer (NSCLC) (Phase 2 portion).
A strategy decision was made not to proceed to Phase 2 portion of this study due to change in standard of care.
Study Locations
Location
Status
Location
University of Alabama at Birmingham - Main /ID# 155135
Birmingham, Alabama, United States, 35233
Status
Not applicable
Location
Icri /Id# 155593
Whittier, California, United States, 90603
Status
Not applicable
Location
Univ of Colorado Cancer Center /ID# 153820
Aurora, Colorado, United States, 80045
Status
Not applicable
Location
University of Chicago /ID# 153824
Chicago, Illinois, United States, 60637-1443
Status
Not applicable
Location
Goshen Center for Cancer Care /ID# 153822
Goshen, Indiana, United States, 46526
Status
Not applicable
Location
Duke University Medical Center /ID# 153821
Durham, North Carolina, United States, 27710-3000
Status
Not applicable