A Study to Assess How the Body Absorbs ABBV-8736 Subcutaneous Injections Relative to Intravenous Injections in Adult Healthy Volunteers

Study Identifier
M25-478
CT.gov Identifier
NCT07413133
EudraCT Identifier
Not available
EUCTIS ID
Not available
For general inquiries, please contact

844-663-3742 or [email protected]

Recruitment Complete
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Study Details

Medical Condition
  • Healthy Volunteer
    • Study Drug
  • ABBV-8736
    • Phase
    Phase 1
    Sex
    Female & Male
    Age
    18 - 60 Years
    Inclusion and Exclusion Criteria
    Inclusion Criteria:
    * Body mass index (BMI) is \>= 18.0 to \<= 32.0 kg/m2 after rounding to the tenths decimal. BMI is calculated as weight in kg divided by the square of height measured in meters. * Body weight \>= 35 kg. * A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12-lead electrocardiogram (ECG).
    Exclusion Criteria:
    * Participant requires any over-the-counter and/or prescription medication, vitamins, and/or herbal supplements, on a regular basis. * Participant uses any medications, vitamins and/or herbal supplements within the 14-day period prior to study treatment administration. * Participant has received any treatment by injection within 30 days or within a period defined by 5 half-lives, whichever is longer, prior to study treatment administration. * Participant has prior exposure to a Triggering Receptor Expressed on Myeloid Cells 1 (TREM1) agent.

    Protocol Summary

    The purpose of this study is to assess the pharmacokinetics (PK), bioavailability, immunogenicity, safety, and tolerability of ABBV-8736 following subcutaneous (SC) administration relative to intravenous (IV) administration.

    Study Locations

    Location
    Status
    Location
    CenExel ACT- Anaheim Clinical Trials /ID# 280481
    Anaheim, California, United States, 92801
    Status
    Not applicable
    Location
    Acpru /Id# 280382
    Grayslake, Illinois, United States, 60030
    Status
    Not applicable