Study of Motexafin Gadolinium for the Treatment of Non-Hodgkin's Lymphoma

Study Identifier
PCYC-0221
CT.gov Identifier
NCT00086034
EudraCT Identifier
Not available
EUCTIS ID
Not available
For general inquiries, please contact

844-663-3742 or [email protected]

Study Complete

Study Details

Medical Condition
  • Blood Cancer - Non-Hodgkin's Lymphoma (General)
    • Study Drug
  • Motexafin gadolinium
    • Phase
    Phase 2
    Sex
    Female & Male
    Age
    18+ years
    Inclusion and Exclusion Criteria
    Inclusion Criteria:
    * ≥ 18 years old * Refractory or relapsed indolent NHL. Eligible WHO histologies include follicular NHL (Grades 1, 2, and 3); marginal zone nodal; marginal zone splenic; and mucosa-associated lymphoid tissue (MALT) types * Failed ≥ 1 previous regimens, one of which must have contained rituximab as either a single agent or in combination with chemotherapy * ECOG performance status score either 0 or 1 * Willing and able to provide written informed consent
    Exclusion Criteria:
    Laboratory values of: * Platelet count \< 50,000/µL * AST or ALT \> 2 x the upper limit of normal (ULN) * Total bilirubin \> 2 x ULN * Creatinine \> 2.0 mg/dL and * Greater than three prior regimens (where a regimen is defined as a treatment for NHL given after disease progression) * Uncontrolled hypertension * Known history of porphyria, G6PD deficiency, HIV

    Protocol Summary

    The primary purpose of this study is to find out if motexafin gadolinium may be an effective treatment for patients with non-Hodgkin's lymphoma (NHL). Secondly, the safety and side effects of motexafin gadolinium will be evaluated.

    Study Locations

    Location
    Status
    Location
    San Diego, California, United States, 92121
    Status
    Not applicable
    Location
    Stanford, California, United States, 94305
    Status
    Not applicable
    Location
    Miami, Florida, United States, 33136
    Status
    Not applicable
    Location
    Chicago, Illinois, United States, 60611
    Status
    Not applicable
    Location
    Baltimore, Maryland, United States, 21231
    Status
    Not applicable
    Location
    Rochester, Minnesota, United States, 55905
    Status
    Not applicable
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